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KMID : 0379120150430010040
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Korean Journal of Mycology
2015 Volume.43 No. 1 p.40 ~ p.46
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Biological Activities of Wild Sparassis crispa Extracts
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Kim Eun-Jung
Yoo Kwan-Hee
Kim Yang-Sup
Seok Soon-Ja
Kim Jun-Ho
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Abstract
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Physiological activities of solvent extracts of Sparassis crispa were investigated for fibrinolytic, thrombin inhibitory, anti-oxidative and anti-inflammatory activities. The fibrinolytic activity was the highest in ethyl acetate extract (2.03 plasmin units/mL) followed by butanol extract (0.70 plasmin units/mL). The ethyl acetate extract exhibited the highest anti-oxidative activity as assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate with a value of 95.94%. The chloroform extract showed thrombin inhibitory activity up to 83.87%. The chloroform extract also showed the highest anti-inflammatory effects on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These findings suggest that Sparassis crispa may be a useful material for development of drugs and functional foods.
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KEYWORD
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Anti-inflammatory activity, Anti-oxidative activity, Fibrinolytic activity, Sparassis crispa, Thrombin inhibitory activity
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